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Sulfatase Families 102 S1 subfamilies · 40,229 sulfatase genes across 32,775 CGCs · 23 subfamilies with characterised activities

S1 sulfatase subfamilies S1 SulfAtlas subfamily numbering · substrate/EC annotations from SulfAtlas (Stam et al. 2023) · S1_0 holds non-sulfatase members (phosphonate monoester hydrolases) and is left out of the totals

FamilyEC numbersActivity (SulfAtlas)GenesCGCs
S1_03.1.-.-Phosphonate monoester hydrolase / phosphodiesterase782781
S1_13.1.6.8Cerebroside sulfohydrolase11
S1_23.1.6.12N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase3,0623,031
S1_33.1.6.2Steryl-sulfate sulfohydrolase5050
S1_43.1.6.1, 3.1.6.-Arylsulfate sulfohydrolase; endo-D-Galactose-3-sulfate 3-O-sulfohydrolase; D-Galactose-6-sulfate 6-O-sulfohydrolase2,2352,217
S1_53.1.6.4[Chondroitin sulfate] N-acetyl-D-galactosamine-6-sulfate 6-O-sulfohydrolase265264
S1_63.1.6.14N-acetyl-D-glucosamine-6-sulfate 6-O-sulfohydrolase4,3904,281
S1_73.1.6.13, 3.1.6.-[heparin/heparan] Iduronate-2-sulfate 2-O-sulfohydrolase; [ulvan] endo-Xylose-2-sulfate 2-O-sulfohydrolase; [k-carrageenan] endo-/exo-Galactose-4-sulfate 4-O-sulfohydrolase3,0772,888
S1_83.10.1.1, 3.1.6.-[heparin/heparan] N-sulfoglucosamine sulfohydrolase; [ulvan] exo-Xylose-2-sulfate 2-O-sulfohydrolase3,4733,327
S1_93.1.6.-△4,5-hexuronate-2-O-sulfate 2-O-sulfohydrolase1,0231,020
S1_113.1.6.11, 3.1.6.14, 3.1.6.-[Heparin/Heparan sulfate] exo-2-N,6-O-disulfo-D-glucosamine 6-O-sulfohydrolase; [Colonic mucin] exo-N-acetyl-D-glucosamine-6-sulfate 6-O-sulfohydrolase; Exo-L-galactose-6-sulfate 6-O-sulfohydrolase1,6861,551
S1_123.1.6.6Choline-sulfate sulfohydrolase837761
S1_133.1.6.-[Fucan sulfated] sulfohydrolase148143
S1_14——1,5131,444
S1_153.1.6.4[Colonic mucin] D-Galactose-6-sulfate/N-acetyl-D-galactosamine-6-sulfate 6-O-sulfohydrolase; [chondroitin sulfate] exo-N-acetyl-D-galactosamine-6-O-sulfate 6-O-sulfohydrolase2,1732,100
S1_163.1.6.12[Colonic mucin] D-Galactose-4-sulfate/N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase2,2242,111
S1_173.1.6.-[fucan] exo-Fucose-2-sulfate 2-O-sulfohydrolase; [a-carrageenan] endo-3,6-anhydro-D-galactose-2-sulfate 2-O-sulfohydrolase1,0231,003
S1_18——3939
S1_193.1.6.-[i-Carrageenan] endo-D-galactose-4-sulfate 4-O-sulfohydrolase (converts i- to a-carrageenan); [k-Carrageenan] exo-D-galactose-4-Sulfate-4-O-sulfohydrolase; [k-Carrageenan] endo-D-galactose-4-sulfate 4-O-sulfohydrolase (converts k- to b-carrageenan)669630
S1_203.1.6.-[Colonic mucin] D-Galactose-3-sulfate 3-O-sulfohydrolase; [Colonic mucin] N-acetyl-D-galactosamine-3-sulfate 3-O-sulfatase796770
S1_21——243242
S1_223.1.6.-[α-(1→3;1→4)-L-fucan] endo-4-sulfate 4-O-sulfohydrolase865856
S1_23——646635
S1_24——685675
S1_253.1.6.-[fucan] exo-Fucose-3-sulfate 3-O-sulfohydrolase; [ulvan] exo-L-Rhamnose-3-sulfate 3-O-sulfohydrolase416415
S1_26——115116
S1_273.1.6.12, 3.1.6.-[chondroitin sulfate/dermatan sulfate] endo-N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase; Ulvan sulfohydrolase1,8311,787
S1_28——303293
S1_29——138136
S1_30——248247
S1_31——155153
S1_32——373371
S1_33——9998
S1_34——109106
S1_35——3838
S1_36——8684
S1_37——1,3871,382
S1_38——1717
S1_39——2222
S1_40——2727
S1_41——172172
S1_43——1110
S1_44——3738
S1_45——55
S1_463.1.6.-[Colonic mucin] exo-N-acetyl-D-glucosamine-3-sulfate 3-O-sulfohydrolase192190
S1_48——3737
S1_49——2828
S1_50——5655
S1_51——7970
S1_52——9595
S1_53——1616
S1_54——1313
S1_55——3030
S1_56——748746
S1_57——44
S1_58——66
S1_59——4544
S1_60——33
S1_61——309293
S1_62——165166
S1_63——2928
S1_64——452442
S1_65——4543
S1_66——11
S1_67——1110
S1_68——66
S1_69——11
S1_70——55
S1_71——9394
S1_72——3230
S1_73——1111
S1_74——33
S1_76——22
S1_77——77
S1_79——1111
S1_80——99
S1_813.1.6.-[carrageenan] exo-3,6-anhydro-D-galactose-2-Sulfate 2-O-sulfohydrolase1111
S1_82——1514
S1_83——87
S1_85——88
S1_86——11
S1_87——33
S1_88——22
S1_90——11
S1_91——44
S1_92——1313
S1_93——22
S1_94——11
S1_95——88
S1_96——11
S1_97——845845
S1_98——22
S1_99——33
S1_100——11
S1_101——11
S1_103——1414
S1_104——44
S1_106——66
S1_107——22
S1_108——66
S1_110——22
S1_N.C——99