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Home · Sulfatase Families
Sulfatase Families 102 subfamilies (S1 type-I superfamily) · 41,302 genes across 39,807 CGCs · 23 subfamilies with characterised activities
S1 sulfatase subfamilies S1
EC numbers + activity descriptions are curated by SulfAtlas; subfamilies without a characterised member show —. Click any subfamily to drill into its phylogeny, SSN, SCoNe, and host distribution.
| Family | EC numbers | Activity (SulfAtlas) | Genes | CGCs |
|---|---|---|---|---|
| S1_0 | 3.1.-.- | Phosphonate monoester hydrolase / phosphodiesterase | 782 | 781 |
| S1_1 | 3.1.6.8 | Cerebroside sulfohydrolase | 1 | 1 |
| S1_2 | 3.1.6.12 | N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase | 3,076 | 3,031 |
| S1_3 | 3.1.6.2 | Steryl-sulfate sulfohydrolase | 50 | 50 |
| S1_4 | 3.1.6.1, 3.1.6.- | Arylsulfate sulfohydrolase; endo-D-Galactose-3-sulfate 3-O-sulfohydrolase; D-Galactose-6-sulfate 6-O-sulfohydrolase | 2,251 | 2,217 |
| S1_5 | 3.1.6.4 | [Chondroitin sulfate] N-acetyl-D-galactosamine-6-sulfate 6-O-sulfohydrolase | 265 | 264 |
| S1_6 | 3.1.6.14 | N-acetyl-D-glucosamine-6-sulfate 6-O-sulfohydrolase | 4,413 | 4,281 |
| S1_7 | 3.1.6.13, 3.1.6.- | [heparin/heparan] Iduronate-2-sulfate 2-O-sulfohydrolase; [ulvan] endo-Xylose-2-sulfate 2-O-sulfohydrolase; [k-carrageenan] endo-/exo-Galactose-4-sulfate 4-O-sulfohydrolase | 3,097 | 2,888 |
| S1_8 | 3.10.1.1, 3.1.6.- | [heparin/heparan] N-sulfoglucosamine sulfohydrolase; [ulvan] exo-Xylose-2-sulfate 2-O-sulfohydrolase | 3,503 | 3,327 |
| S1_9 | 3.1.6.- | △4,5-hexuronate-2-O-sulfate 2-O-sulfohydrolase | 1,030 | 1,020 |
| S1_11 | 3.1.6.11, 3.1.6.14, 3.1.6.- | [Heparin/Heparan sulfate] exo-2-N,6-O-disulfo-D-glucosamine 6-O-sulfohydrolase; [Colonic mucin] exo-N-acetyl-D-glucosamine-6-sulfate 6-O-sulfohydrolase; Exo-L-galactose-6-sulfate 6-O-sulfohydrolase | 1,702 | 1,551 |
| S1_12 | 3.1.6.6 | Choline-sulfate sulfohydrolase | 839 | 761 |
| S1_13 | 3.1.6.- | [Fucan sulfated] sulfohydrolase | 148 | 143 |
| S1_14 | — | — | 1,517 | 1,444 |
| S1_15 | 3.1.6.4 | [Colonic mucin] D-Galactose-6-sulfate/N-acetyl-D-galactosamine-6-sulfate 6-O-sulfohydrolase; [chondroitin sulfate] exo-N-acetyl-D-galactosamine-6-O-sulfate 6-O-sulfohydrolase | 2,219 | 2,100 |
| S1_16 | 3.1.6.12 | [Colonic mucin] D-Galactose-4-sulfate/N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase | 2,242 | 2,111 |
| S1_17 | 3.1.6.- | [fucan] exo-Fucose-2-sulfate 2-O-sulfohydrolase; [a-carrageenan] endo-3,6-anhydro-D-galactose-2-sulfate 2-O-sulfohydrolase | 1,033 | 1,003 |
| S1_18 | — | — | 39 | 39 |
| S1_19 | 3.1.6.- | [i-Carrageenan] endo-D-galactose-4-sulfate 4-O-sulfohydrolase (converts i- to a-carrageenan); [k-Carrageenan] exo-D-galactose-4-Sulfate-4-O-sulfohydrolase; [k-Carrageenan] endo-D-galactose-4-sulfate 4-O-sulfohydrolase (converts k- to b-carrageenan) | 676 | 630 |
| S1_20 | 3.1.6.- | [Colonic mucin] D-Galactose-3-sulfate 3-O-sulfohydrolase; [Colonic mucin] N-acetyl-D-galactosamine-3-sulfate 3-O-sulfatase | 802 | 770 |
| S1_21 | — | — | 246 | 242 |
| S1_22 | 3.1.6.- | [α-(1→3;1→4)-L-fucan] endo-4-sulfate 4-O-sulfohydrolase | 869 | 856 |
| S1_23 | — | — | 658 | 635 |
| S1_24 | — | — | 692 | 675 |
| S1_25 | 3.1.6.- | [fucan] exo-Fucose-3-sulfate 3-O-sulfohydrolase; [ulvan] exo-L-Rhamnose-3-sulfate 3-O-sulfohydrolase | 420 | 415 |
| S1_26 | — | — | 116 | 116 |
| S1_27 | 3.1.6.12, 3.1.6.- | [chondroitin sulfate/dermatan sulfate] endo-N-acetyl-D-galactosamine-4-sulfate 4-O-sulfohydrolase; Ulvan sulfohydrolase | 1,853 | 1,787 |
| S1_28 | — | — | 307 | 293 |
| S1_29 | — | — | 138 | 136 |
| S1_30 | — | — | 251 | 247 |
| S1_31 | — | — | 155 | 153 |
| S1_32 | — | — | 374 | 371 |
| S1_33 | — | — | 100 | 98 |
| S1_34 | — | — | 109 | 106 |
| S1_35 | — | — | 38 | 38 |
| S1_36 | — | — | 86 | 84 |
| S1_37 | — | — | 1,388 | 1,382 |
| S1_38 | — | — | 17 | 17 |
| S1_39 | — | — | 22 | 22 |
| S1_40 | — | — | 27 | 27 |
| S1_41 | — | — | 172 | 172 |
| S1_43 | — | — | 11 | 10 |
| S1_44 | — | — | 38 | 38 |
| S1_45 | — | — | 5 | 5 |
| S1_46 | 3.1.6.- | [Colonic mucin] exo-N-acetyl-D-glucosamine-3-sulfate 3-O-sulfohydrolase | 193 | 190 |
| S1_48 | — | — | 37 | 37 |
| S1_49 | — | — | 28 | 28 |
| S1_50 | — | — | 56 | 55 |
| S1_51 | — | — | 79 | 70 |
| S1_52 | — | — | 95 | 95 |
| S1_53 | — | — | 16 | 16 |
| S1_54 | — | — | 13 | 13 |
| S1_55 | — | — | 30 | 30 |
| S1_56 | — | — | 752 | 746 |
| S1_57 | — | — | 4 | 4 |
| S1_58 | — | — | 6 | 6 |
| S1_59 | — | — | 45 | 44 |
| S1_60 | — | — | 3 | 3 |
| S1_61 | — | — | 310 | 293 |
| S1_62 | — | — | 167 | 166 |
| S1_63 | — | — | 29 | 28 |
| S1_64 | — | — | 456 | 442 |
| S1_65 | — | — | 45 | 43 |
| S1_66 | — | — | 1 | 1 |
| S1_67 | — | — | 11 | 10 |
| S1_68 | — | — | 6 | 6 |
| S1_69 | — | — | 1 | 1 |
| S1_70 | — | — | 5 | 5 |
| S1_71 | — | — | 96 | 94 |
| S1_72 | — | — | 32 | 30 |
| S1_73 | — | — | 11 | 11 |
| S1_74 | — | — | 3 | 3 |
| S1_76 | — | — | 2 | 2 |
| S1_77 | — | — | 7 | 7 |
| S1_79 | — | — | 11 | 11 |
| S1_80 | — | — | 10 | 9 |
| S1_81 | 3.1.6.- | [carrageenan] exo-3,6-anhydro-D-galactose-2-Sulfate 2-O-sulfohydrolase | 11 | 11 |
| S1_82 | — | — | 15 | 14 |
| S1_83 | — | — | 8 | 7 |
| S1_85 | — | — | 8 | 8 |
| S1_86 | — | — | 1 | 1 |
| S1_87 | — | — | 3 | 3 |
| S1_88 | — | — | 2 | 2 |
| S1_90 | — | — | 1 | 1 |
| S1_91 | — | — | 4 | 4 |
| S1_92 | — | — | 13 | 13 |
| S1_93 | — | — | 2 | 2 |
| S1_94 | — | — | 1 | 1 |
| S1_95 | — | — | 8 | 8 |
| S1_96 | — | — | 1 | 1 |
| S1_97 | — | — | 846 | 845 |
| S1_98 | — | — | 2 | 2 |
| S1_99 | — | — | 3 | 3 |
| S1_100 | — | — | 1 | 1 |
| S1_101 | — | — | 1 | 1 |
| S1_103 | — | — | 14 | 14 |
| S1_104 | — | — | 4 | 4 |
| S1_106 | — | — | 6 | 6 |
| S1_107 | — | — | 2 | 2 |
| S1_108 | — | — | 6 | 6 |
| S1_110 | — | — | 2 | 2 |
| S1_N.C | — | — | 0 | 9 |